Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.
Identifieur interne : 005217 ( Main/Exploration ); précédent : 005216; suivant : 005218Overexpression of 7a, a protein specifically encoded by the severe acute respiratory syndrome coronavirus, induces apoptosis via a caspase-dependent pathway.
Auteurs : Yee-Joo Tan [Singapour] ; Burtram C. Fielding ; Phuay-Yee Goh ; Shuo Shen ; Timothy H P. Tan ; Seng Gee Lim ; Wanjin HongSource :
- Journal of virology [ 0022-538X ] ; 2004.
Descripteurs français
- KwdFr :
- Animaux, Apoptose, Caspase-3, Caspases (métabolisme), Cellules COS, Cellules HeLa, Cellules Vero, Humains, Lignée cellulaire, Protéines de la matrice virale, Protéines membranaires (génétique), Protéines membranaires (métabolisme), Protéines virales (génétique), Protéines virales (métabolisme), Virus du SRAS (génétique), Virus du SRAS (pathogénicité).
- MESH :
- génétique : Protéines membranaires, Protéines virales, Virus du SRAS.
- métabolisme : Caspases, Protéines membranaires, Protéines virales.
- pathogénicité : Virus du SRAS.
- Animaux, Apoptose, Caspase-3, Cellules COS, Cellules HeLa, Cellules Vero, Humains, Lignée cellulaire, Protéines de la matrice virale.
English descriptors
- KwdEn :
- Animals, Apoptosis, COS Cells, Caspase 3, Caspases (metabolism), Cell Line, Chlorocebus aethiops, HeLa Cells, Humans, Membrane Proteins (genetics), Membrane Proteins (metabolism), SARS Virus (genetics), SARS Virus (pathogenicity), Vero Cells, Viral Matrix Proteins, Viral Proteins (genetics), Viral Proteins (metabolism).
- MESH :
- chemical , genetics : Membrane Proteins, Viral Proteins.
- chemical , metabolism : Caspases, Membrane Proteins, Viral Proteins.
- chemical : Caspase 3, Viral Matrix Proteins.
- genetics : SARS Virus.
- pathogenicity : SARS Virus.
- Animals, Apoptosis, COS Cells, Cell Line, Chlorocebus aethiops, HeLa Cells, Humans, Vero Cells.
Abstract
Besides genes that are homologous to proteins found in other coronaviruses, the severe acute respiratory syndrome coronavirus genome also contains nine other potential open reading frames. Previously, we have characterized the expression and cellular localization of two of these "accessory" viral proteins, 3a (previously termed U274) and 7a (previously termed U122). In this study, we further examined whether they can induce apoptosis, which has been observed clinically. We showed that the overexpression of 7a, but not of 3a or the viral structural proteins, nucleocapsid, membrane, and envelope, induces apoptosis. 7a induces apoptosis via a caspase-dependent pathway and in cell lines derived from different organs, including lung, kidney, and liver.
DOI: 10.1128/JVI.78.24.14043-14047.2004
PubMed: 15564512
Affiliations:
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Le document en format XML
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Fielding</name></author><author><name sortKey="Goh, Phuay Yee" sort="Goh, Phuay Yee" uniqKey="Goh P" first="Phuay-Yee" last="Goh">Phuay-Yee Goh</name></author><author><name sortKey="Shen, Shuo" sort="Shen, Shuo" uniqKey="Shen S" first="Shuo" last="Shen">Shuo Shen</name></author><author><name sortKey="Tan, Timothy H P" sort="Tan, Timothy H P" uniqKey="Tan T" first="Timothy H P" last="Tan">Timothy H P. 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Fielding</name></author><author><name sortKey="Goh, Phuay Yee" sort="Goh, Phuay Yee" uniqKey="Goh P" first="Phuay-Yee" last="Goh">Phuay-Yee Goh</name></author><author><name sortKey="Shen, Shuo" sort="Shen, Shuo" uniqKey="Shen S" first="Shuo" last="Shen">Shuo Shen</name></author><author><name sortKey="Tan, Timothy H P" sort="Tan, Timothy H P" uniqKey="Tan T" first="Timothy H P" last="Tan">Timothy H P. Tan</name></author><author><name sortKey="Lim, Seng Gee" sort="Lim, Seng Gee" uniqKey="Lim S" first="Seng Gee" last="Lim">Seng Gee Lim</name></author><author><name sortKey="Hong, Wanjin" sort="Hong, Wanjin" uniqKey="Hong W" first="Wanjin" last="Hong">Wanjin Hong</name></author></analytic><series><title level="j">Journal of virology</title><idno type="ISSN">0022-538X</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>COS Cells</term><term>Caspase 3</term><term>Caspases (metabolism)</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>HeLa Cells</term><term>Humans</term><term>Membrane Proteins (genetics)</term><term>Membrane Proteins (metabolism)</term><term>SARS Virus (genetics)</term><term>SARS Virus (pathogenicity)</term><term>Vero Cells</term><term>Viral Matrix Proteins</term><term>Viral Proteins (genetics)</term><term>Viral Proteins (metabolism)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Caspase-3</term><term>Caspases (métabolisme)</term><term>Cellules COS</term><term>Cellules HeLa</term><term>Cellules Vero</term><term>Humains</term><term>Lignée cellulaire</term><term>Protéines de la matrice virale</term><term>Protéines membranaires (génétique)</term><term>Protéines membranaires (métabolisme)</term><term>Protéines virales (génétique)</term><term>Protéines virales (métabolisme)</term><term>Virus du SRAS (génétique)</term><term>Virus du SRAS (pathogénicité)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Membrane Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Caspases</term><term>Membrane Proteins</term><term>Viral Proteins</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Caspase 3</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Protéines membranaires</term><term>Protéines virales</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Caspases</term><term>Protéines membranaires</term><term>Protéines virales</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>SARS Virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus du SRAS</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Apoptosis</term><term>COS Cells</term><term>Cell Line</term><term>Chlorocebus aethiops</term><term>HeLa Cells</term><term>Humans</term><term>Vero Cells</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Apoptose</term><term>Caspase-3</term><term>Cellules COS</term><term>Cellules HeLa</term><term>Cellules Vero</term><term>Humains</term><term>Lignée cellulaire</term><term>Protéines de la matrice virale</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Besides genes that are homologous to proteins found in other coronaviruses, the severe acute respiratory syndrome coronavirus genome also contains nine other potential open reading frames. Previously, we have characterized the expression and cellular localization of two of these "accessory" viral proteins, 3a (previously termed U274) and 7a (previously termed U122). In this study, we further examined whether they can induce apoptosis, which has been observed clinically. We showed that the overexpression of 7a, but not of 3a or the viral structural proteins, nucleocapsid, membrane, and envelope, induces apoptosis. 7a induces apoptosis via a caspase-dependent pathway and in cell lines derived from different organs, including lung, kidney, and liver.</div></front></TEI><affiliations><list><country><li>Singapour</li></country></list><tree><noCountry><name sortKey="Fielding, Burtram C" sort="Fielding, Burtram C" uniqKey="Fielding B" first="Burtram C" last="Fielding">Burtram C. Fielding</name><name sortKey="Goh, Phuay Yee" sort="Goh, Phuay Yee" uniqKey="Goh P" first="Phuay-Yee" last="Goh">Phuay-Yee Goh</name><name sortKey="Hong, Wanjin" sort="Hong, Wanjin" uniqKey="Hong W" first="Wanjin" last="Hong">Wanjin Hong</name><name sortKey="Lim, Seng Gee" sort="Lim, Seng Gee" uniqKey="Lim S" first="Seng Gee" last="Lim">Seng Gee Lim</name><name sortKey="Shen, Shuo" sort="Shen, Shuo" uniqKey="Shen S" first="Shuo" last="Shen">Shuo Shen</name><name sortKey="Tan, Timothy H P" sort="Tan, Timothy H P" uniqKey="Tan T" first="Timothy H P" last="Tan">Timothy H P. Tan</name></noCountry><country name="Singapour"><noRegion><name sortKey="Tan, Yee Joo" sort="Tan, Yee Joo" uniqKey="Tan Y" first="Yee-Joo" last="Tan">Yee-Joo Tan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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